Inclusion Complex of Artemether with 2-Hydroxypropyl -β-Cyclodextrin for the Treatment of Malaria: Preparation, Characterization and Evaluation

Malaria has a serious influence on human beings especially on that in tropical and subtropical countries. It is reported that there are approximately 300-500 million in clinical and 1.5-2.7 million in death every year. Among them, Plasmodium falciparum is the main protozoon for fatal cases [1]. With the widespread drug resistance limited by older therapies dominated by quinine, standard therapy for malaria is now artemisinin-based chemotherapy which is genuine and of high quality [2]. Artemether,[3R(3R,5aS,6S,8aS,9R,10R,12S,12aR)]-Decahydro-10-methoxy-3,6,9trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin [3], is one of the lipid-soluble derivative of artemisinin, which has proved to be efficient against malaria especially for malignant malaria [4]. The structural formula is shown in Figure 1A. ATM disturbs the mitochondrial function, influence ultrastructure, and block the nutritional intake of Plasmodium falciparum, making them to lose cytoplasm and nutrients and cannot get replenish and soon died [5,6].